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ea0081p393 | Environmental Endocrinology | ECE2022

Dioxin-like polychlorinated biphenyl (pcbs) congeners induce inflammatory responses and reduce thyroid-specific genes expression in human thyrocytes via ahr pathways

Ruggeri Rosaria , Minuti Aurelio , Aliquo Federica , Giani Fiorenza , Masto Roberta , Romano Davide , Avenoso Angela , Teresa Cristani Maria , Trimarchi Francesco , Campenni Alfredo , D'Ascola Angela , Cannavo Salvatore

Background: PCBs are persistent organic pollutants, able to affect thyroid function (endocrine disruptors) and promote inflammation through multiple mechanisms. The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor able to bind dioxins and dioxin-like pollutants including PCBs, play a key role in xenobiotic response, by up-regulating specific responsive genes, the so-called AhR gene battery, including cytochrome P450 1A1 (CYP1A1) and Nuclear ...

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Endocrine Abstracts

Dioxin-like polychlorinated biphenyl (pcbs) congeners induce inflammatory responses and reduce thyroid-specific genes expression in human thyrocytes via ahr pathways

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